EFA, particularly linoleic acid, are necessary for a good epidermal barrier function( control of water loss across the epidermis, decrease allergen penetration); linoleic acid is a major component of the lamellae which holds the cells of the stratum corneum together.
Evans says previously researchers had proposed that the stratum corneum had a structure that was capable of expanding as it absorbed water.
Transdermal drug delivery is limited by the extraordinary barrier properties of the stratum corneum, the outer skin.
Objective To study the effect of skin stratum corneum on transdermal absorption characteristic of Sinomenine Liposome Patch.
By disrupting the stratum corneum structure and create pathways allowing transport of macromolecules, microneedles array can improve the transdermal drug delivery and increase the efficiency.
Excessive focal pressure developed during the midstance and heel-rise parts of the gait cycle may cause skin loss or hypertrophy of the stratum corneum (callus) over bony prominences.
It will effectively remove the dirt, keep the balance of skin's moisture relieves skin's fatigue to soften stratum corneum, replenish damage skin cells, regain skin cells activity.
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