One interesting fact to be aware of: If you're still smoking, your sputum production may not increase despite advancing COPD, whereas sputum production tends to increase after you quit.
The system could also diagnose sickle-cell anaemia from blood samples, while fluorescent images of a stained sputum smear were sufficient to identify the presence of tuberculosis.
A non-productive cough does not expel sputum from the respiratory tract.
Is there any blood in your stool (urine, sputum)?