Methods Apraclonidine was synthesized from P-Nitraniline by reaction with reduction, adding protection group, formylation, chlorination, cyclization, off-protecting group.
Large amounts of formaldehyde are used in the manufacture of various familiar plastics. The reaction of formaldehyde with proteins (called amino formylation) leads to its use in the tanning industry and for treating various vegetable proteins to render them fibrous.