Cyproheptadine, the 5-ht antagonist, was able to selectively blockade the excitatory effect of 5-ht on the fluke, and a similar effect was observed in mammalian animals.
It has been demonstrated that Schistosome is pathogen of schistosomiasis, and the mammalian animal (the end host) and snails (the intermediate host) are their two hosts.
In the time when the dinosaurs dominated the daytime economy, our mammalian ancestors probably only managed to survive at all because they found ways of scraping a living at night.