Prospective cohort studies have shown no differences in effectiveness or acceptability between home-based and clinic-based medical abortion across countries.
The cohort studies (macro studies) could be divided into two types in terms of the scopes of research works. One is thematic macro study and the other is general history macro study.
Without any available cohort studies to test exposure over a long period of time, though, they have had to rely on lab studies, which failed to find any clear or reproducible biological effects.