It'll make a great difference if you're late.
The very short wave lengths of ultrasound make a great difference in what ordinary sound waves can do.
Lisas money will make a great difference to a man of Guy's tastes, who has been feeling the pinch lately.
What we need to do is just to correct some little ignorant habits, and the we will make a great difference.
The closure of the local bus service will make a great difference to their everyday lives.
Regular exercise can make a great difference to you life.
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