Multiple myeloma is a cancer of blood plasma cells.
Antibodies produced by plasma cells bind to antigen-bearing cells, marking them for destruction.
Bone marrow transplantation is a treatment option for patients with life-threatening diseases such as blood-related cancers, plasma cell disorders, and certain inherited immune system disorders.
Usually, the plasma cells are differentiated enough to retain the function of immunoglobulin production.
This is the appearance of normal bone marrow smear at high magnification. Note the presence of an eosinophilic myelocyte, a basophilic myelocyte, and a plasma cell.
At low power, the abnormal plasma cells of multiple myeloma fill the marrow.
"When a B cell binds to an antigen, it multiplies to form a clone of identical cells. Some of these, acted on by helper T cells, differentiate into plasma cells that produce antibodies against the antigen. Others (memory cells) multiply, providing long-term immunity to the antigen. "
ObjectiveTo study the characteristics histologic and cytologic features and clinical usefulness of plasma cell myeloma (PCM) subtyping according to WHO PCM classification.
However, the plasma cells are most characteristic for chronic pyelonephritis.
Therefore, each initially stimulated B cell produces a clone of plasma cells, all producing the same specific antibody.
Objective To explore the clinical characteristics of primary plasma cell leukemia(PPCL).
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