When given by most routes (excluding iv), a drug must traverse several semipermeable cell membranes before reaching the systemic circulation.
It is essentially a long, closed tube through which Blood moves in a double circuit-one through the lungs (pulmonary circulation) and one through the rest of the Body (systemic circulation).
It is directly proportional to the total amount of unchanged drug that reaches the systemic circulation.
An embolus from a cardiac valvular vegetation from the left side of the heart can travel out the systemic circulation.
Process of drug movement from the administration site to the systemic circulation.
The left atrium takes in Blood from the pulmonary veins and sends it into the systemic circulation.
Potassium is released from ischemic muscle into systemic circulation, causing hyperkalemia.
Conclusion Propofol can reduce the changes of HR, and protect the function of systemic circulation, pulmonary circulation and ci during acute myocardial ischemia-reperfusion injury in a canine model.
Objective To investigate the vessel origin of systemic circulation that supplies the lungs and the techniques of arterial embolism applied to large hemoptysis.
As it degrades over the course of months, the tube "gives the space for cells to grow and regenerate to extend systemic circulation, " said Alejandro Nieponice, who also worked on the study.
The model contains left ventricle(LV), left atrium, systemic circulation, aortic valve and mitral valve; it simulated the hemodynamics phenomena of left heart circulation.
The volume of the systemic circulation is about 7 times that of the pulmonary system.
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