Macromolecules cannot approach the ligand owing to steric hindrance of the matrix.
Synthesis and application of lauric acid ester quaternary ammonium salt cationic surfactant in condition of steric hindrance
The dispersing ability of SSHE as cement dispersant also came from steric hindrance effect and long side chain contributed to steric hindrance in a certain degree.
The large steric hindrance group avails to the enantioselectivity, but too much steric hindrance reduces the activity.