The present, first-generation blood substitutes are mainly effective for short-term uses because of their brief circulation time.
One method is to encapsulate hemoglobin inside lipid vesicles about 0.2 microns (millionths of a meter) in diameter. This technique also increases the circulation time.
Silver, because the circulation time is short, there is very little, the modern mechanism of the famous silver treasures, this gold casting precision.